Candid ointment d instructions for use. Candide cream (ointment): detailed instructions and recommendations for use, composition, review of analogues. Description of the dosage form

Candide is a drug (tablets) that corresponds to the group of antiseptics and antimicrobial drugs for the treatment of gynecological diseases. The drug is characterized by the following application features:

During pregnancy: contraindicated
When breastfeeding: with caution

Packaging

Composition

Cream Candide contains the active ingredient clotrimazole, as well as auxiliary components: white petrolatum, propylene glycol, emulsion cetomacrogol wax, liquid paraffin, butylhydroxytoluene, propyl parahydroxybenzoate, methyl parahydroxybenzoate, benzyl alcohol, purified sodium hydrogen phosphate, sodium dihydrogen phosphate, sodium dihydrogen phosphate.

The Candide solution contains the active ingredient clotrimazole, as well as glycerol and propylene glycol as additional components.

Vaginal tablets contain clotrimazole as an active ingredient, as well as additional ingredients: purified talc, starch, magnesium stearate, lactose, silicon dioxide, propylparaben, methyl parahydroxybenzoate, sodium carboxymethyl starch.

Release form

The medicine has several forms of release. Currently, Candide gel 2%, cream for external use 1%, powder for external use 1%, solution for local use 1%, and vaginal tablets (suppositories) Candide are produced.

The cream is a homogeneous white substance contained in a 20 g aluminum tube.
Solution for topical application, transparent, colorless, has a viscous consistency. The bottle contains 15 g of the product.
Powder for external use (dusting) is contained in a plastic bottle of 30 g.

pharmachologic effect

The drug produces a local antibacterial and antifungal effect, also has an antiprotozoal and trichomonacid effect. There is a wide range of antifungal effects.

The antimycotic effect of clotrimazole (the active component of the drug is an imidazole derivative) occurs due to a disruption in the synthesis of ergosterol, which is part of the fungal cell membrane. As a result, membrane permeability changes and subsequent cell lysis occurs.

The interaction of fungicidal concentrations with mitochondrial and peroxidase enzymes is noted, and as a result, the concentration of hydrogen peroxide increases to the level of toxicity. As a result, fungal cells are destroyed.

Fungistatic and fungicidal activity was noted against dermatomycetes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), mold and yeast-like fungi (fungi Candida spp., Torulopsis glabrata or Porsche)

Also, clotrimazole demonstrates activity against the causative agent of varicolored lichen.

The agent is effective against gram-positive bacteria and a number of gram-negative bacteria. Provided that high concentrations are used, the agent is active against Trichomonas vaginalis.

Pharmacokinetics and pharmacodynamics

Clotrimazole is poorly absorbed through the skin and mucous membranes, therefore, when the drug is used externally, systemic action is not observed. When applied externally in the epidermis, a higher concentration of clotrimazole is observed than in the subcutaneous tissue and in the dermis.

When administered intravaginally, the absorption of clotrimazole is equal to 3% to 10% of the dose that is administered. Within 2 to 3 days, there are low concentrations of the active substance in the blood and a high level of concentration in the vaginal secretion.

The metabolism of clotrimazole in the liver is noted.

Indications for use

The drug Candide is used if the patient has the following diseases or symptoms:

pityriasis versicolor, versicolor versicolor;
mycoses and skin folds;
erythrasma;
superficial candidiasis, which cause yeast, mold and other fungi, dermatophytes, as well as a number of other pathogens demonstrating sensitivity to clotrimazole;
mycoses, in which there is a complication of secondary pyoderma;
candidal vulvitis;
candidal balanitis;
candidiasis of the skin;
candidal paronychia;
candidiasis of the anus and external genitals;
fungal diaper dermatitis.

Solution Candide for the oral cavity is used for stomatitis of candidal origin.

Vaginal tablets are used to treat genital infections, as well as genital superinfections provoked by microorganisms sensitive to clotrimazole.

Candide is also used to sanitize the birth canal during preparation for childbirth.

Contraindications

Gel, cream, drops of Candide and other forms of the drug are not used in case of hypersensitivity to clotrimazole or to other components of this drug. Not prescribed during menstruation, in the first trimester of pregnancy, carefully used to treat women during breastfeeding.

Side effects

The manifestation of the following side effects may develop when using this remedy:

hives, itching, burning and tingling sensations where the cream was applied;
erythema, edema, blisters, peeling and irritation of the skin.

If such manifestations are noted, Candide and Candide B ointment should be canceled.

When using Candida intravaginally, the development of local irritation is rarely noted, which, as a rule, disappears on its own with further treatment. Also, with intravaginal use of the drug, the development of such negative effects is possible:

itching, burning;
discharge from the vagina and swelling of its mucous membrane;
headache;
frequent urination and intercurrent cystitis;
pain during intercourse;
a burning sensation in the genitals of a man.

Application instruction of Candida (Way and dosage)

Cream Candide, instructions for use

Ointment is applied externally. Before applying the product, you must first clean and dry those areas of the skin that have been affected. For cleaning, use soap with a neutral pH value. The cream is applied in a thin layer and gently rubbed into the skin, doing this two to three times a day. The treatment lasts as long as the doctor prescribes. Its duration depends on the location and severity of the disease, as well as on the effectiveness of treatment.

In the treatment of dermatomycosis, the course of application is at least 4 weeks; in the treatment of pityriasis versicolor, the cream should be applied from 1 to 3 weeks. For people who suffer from fungal diseases of the skin of the feet, the cream should be regularly applied for at least two weeks after the symptoms of the disease have disappeared.

How to use the gel also depends on the severity and characteristics of the course of the disease. As a rule, the agent is rubbed into the affected area 2-3 times a day. It is advisable to apply the gel for another 3-4 weeks in order to completely eliminate possible relapses.

Solution Candide, instructions for use

The agent in the form of a solution is prescribed for large lesions of the skin, as well as for lesions of the scalp. If Candide drops are prescribed to the patient, the instructions for use must be carefully followed. If the oral cavity is damaged with a cotton swab, the solution is applied in 10-20 drops, doing this 3-4 times a day. It is important to treat all affected areas very carefully. Use the product until the clinical symptoms disappear.

Powder instruction

Powder Candide is applied externally, it must be applied to the areas of the skin that have been affected 3-4 times a day. It is important to apply the product regularly. The duration of therapy depends on the severity of the disease, as well as on the localization of the disease. In order to completely cure the disease, sometimes treatment continues even after the expressed symptoms disappear. The duration of treatment is usually 4 weeks. Patients with pityriasis versicolor are recommended to use the drug for 1-3 weeks, patients suffering from erythrasma are shown to be treated for 2-4 weeks.

The drug in the form of vaginal tablets is injected intravaginally, this must be done in the supine position, with the legs bent. It is necessary to use the tablets once a day, before bedtime. In order to sanitize the birth canal, one tablet (500 mg of the drug) is administered.

Overdose

When using the cream in high doses, there are no manifestations of reactions, as well as life-threatening conditions.

If the drug was taken orally, the patient may develop nausea, vomiting, gastralgia, anorexia, pollakiuria, and allergic manifestations. Development of hallucinations, drowsiness is rarely noted. There is no specific antidote; when taken orally, Candide drugs are prescribed to take activated carbon, symptomatic therapy is also practiced.

Interaction

The effect of clotrimazole is reduced with the simultaneous use of Nystatin, Amphotericin B, Natamycin, which is why Candide ointment and other forms of the drug should not be used in the treatment of the listed drugs.

In general, when the cream is used simultaneously with other drugs, the negative effects of other drugs are not known, since there is a low resorption capacity of clotrimazole.

Terms of sale

Available without a doctor's prescription.

Storage conditions

It is necessary to protect all forms of Candida from children, store at a temperature of 2 to 25 ° C.

Shelf life

You can store Candide ointment for 4 years, Candide solution can be stored for 3 years.

special instructions

Do not apply the product to the skin around the eyes.

When using the drug, you should periodically monitor the state of the liver of a patient who suffers from liver failure.

If signs of high sensitivity appear during use, treatment with the drug should be discontinued.

If, when using the remedy for 4 weeks, there is no effect of treatment, it is necessary to confirm the diagnosis by visiting a specialist.

The use of the product does not affect the ability to drive vehicles and work with precise mechanisms.

Do not apply the product for external use on those areas of the skin on which there are violations of integrity.

To prevent the development of urogenital reinfection, it is important to carry out simultaneous treatment of both sexual partners.

If the vagina and labia are affected, Candide cream and vaginal tablets should be used simultaneously.

Analogs

A number of drugs with a similar effect are produced. These are drugs Antifungol, Imidil cream, Imidil, Kandizol, Amiklon, Kanesten, Candid-B6, Clotrimazole, Kandibene, etc. The price of analogs depends on the manufacturer, form of release, packaging of the drug.

Cream Candide and Candide B have a similar effect, but Candide B, in addition to clotrimazole, also contains beclomethasone as an active ingredient.

For kids

Remedy Candide in the form of a solution is used for stomatitis in children, it must be used according to the instructions and on the recommendation of a doctor. The tool is also used in the treatment of a number of fungal diseases, in particular, it is used to treat babies from thrush. Candide from thrush in newborns and children is used strictly as prescribed by the doctor.

Candide for newborns

Solution Candide for newborns is used to treat candidiasis in infants. It is necessary to carry out procedures for thrush in infants after feeding. To carry out such a procedure, a few drops of solution (3-4 drops) are applied to a cotton swab or tampon, after which they gently lubricate those areas in the oral cavity that have been affected. This procedure should be carried out three times a day. Already after 2-3 days, there should be clear signs of improvement.

During pregnancy and lactation

There is no clinically established data that the use of Candide medication locally during pregnancy, as well as during breastfeeding, adversely affects the health of a woman or an unborn child. But it is important that the decision on the use of the drug during the second and third trimester of pregnancy, as well as during lactation, is made by the doctor.

Do not apply the product to the mammary glands during lactation.

Candide cream is an antifungal agent that helps get rid of fungal infection in various areas skin and mucous membranes. The drug eliminates the symptoms of the fungus and completely neutralizes the inflammation focus. Appointed for adults and children.

Description of the drug

Candide cream is an effective, safe and well-tolerated drug. It is widely used in the treatment of thrush, skin, vulvovaginal and oropharyngeal fungal infections.

The tool has minor side effects and an uncomplicated metabolic profile. It is used worldwide for the treatment of mycotic diseases such as vaginal yeast infections and fungal infections of the skin and nails.

Skin infections caused by candida or dermatophytes can be effectively treated with topical application of clotrimazole as a cream and ointment.

Candide is well tolerated and does not cause undesirable reactions in patients.

Release form and price

Cream Candide 1% is sold in the pharmacy chain in aluminum tubes of 20 grams. Manufacturer - India. The price of the cream is on average 500 rubles.

Composition

The main active ingredient medicinal product - clotrimazole.

It inhibits the biosynthesis of ergosterol, an important component of fungal cell membranes. Clotrimazole increases the permeability of the fungal cell membrane, which leads to the destruction of the enzyme systems of the fungus. The substance provokes leakage and loss of essential intracellular compounds and ultimately causes cell lysis.

Clotrimazole is a synthetic imidazole derivative mainly used topically in the treatment of vaginal and skin infections caused by yeast and dermatophytes. The drug is most active against Candida spp., Trichophyton spp., Microsporum spp. and Malazzesia fuffur (Pityrosporon orbiculare). In addition, it is active against some gram-positive bacteria and, at very high concentrations, kills Trichomonas spp.

Due to its effectiveness, clotrimazole is included in the list of essential medicines by the World Health Organization.

Pharmacodynamics

All azole-type antifungals interfere with the biosynthesis of ergosterol, which is considered the main component of the fungal cytoplasmic membrane.

Ergosterol performs a function similar to cholesterol in animal cell membranes.

Azoles, including clotrimazole, inhibit microsomal cytochrome P450. It is considered a vital step in the biosynthesis of ergosterol in fungi. The resulting depletion of ergosterol and its replacement with aberrant types of sterols disrupt normal membrane permeability and increase fluidity. Subsequent effects include a decrease in the activity of membrane-bound enzymes, including those directly involved in cell wall biosynthesis. The drug causes increased cell wall permeability and leakage of its contents. Since ergosterol directly stimulates the growth of fungal cells in a hormone-like manner, treatment with the drug results in a dose- and time-dependent inhibition of the growth of pathogenic fungi.

Clotrimazole is considered fungistatic rather than fungicidal, although, as with many antimicrobial drugs, this distinction is not absolute as it exhibits fungicidal activity at higher concentrations.

Pharmacokinetics

Minimal systemic absorption is observed after application of Candide cream to the skin. High concentrations of the drug are present in the stratum corneum; lower drug concentrations are found in the papillary and reticular dermis.

About 3-10% of the intravaginal dose of the drug reaches the systemic circulation, mainly in the form of metabolites.

Indications

Dermatophytosis in the head area (including in the face area), trunk, lower extremities;
Fungal nail infection;
Versicolor versicolor;
Skin candidiasis;
Candidal paronychia;
Fungal infection of the external genital organs in women;
Candidal balanitis in men;
Candidiasis in the area of \u200b\u200bthe external genital organs and anorectal region;
Diaper dermatitis of fungal etiology;
Erythrasma.

Contraindications

Candide is not prescribed for hypersensitivity to clotrimazole or to other constituent elements of the drug.

Side effect

The drug is dispensed in any pharmacy without a prescription and is considered safe without serious side effects. A small number of cases of allergic contact dermatitis have been reported that are caused by the active ingredient.

Patients should be aware that intravaginal clotrimazole can damage latex contraceptives (condoms), which requires the use of additional contraceptive measures during the treatment period.

Overdose

Currently, no cases of Candide cream overdose have been reported.

Drug interactions

The activity of Candida decreases with simultaneous treatment with drugs containing nystatin.

Can be used safely while drinking alcohol, does not affect the ability to drive a car.

During pregnancy and hepatitis B

The use of Candide is prohibited in the first trimester of pregnancy. In the last months of bearing a child, the use of an intravaginal applicator is not recommended.

The instruction of the cream says that the safety of use drug during lactation has not been established. Doctors recommend avoiding application to large areas of the skin for a long time.

Candide for children

The drug is indicated for the fight against fungal skin diseases in children from birth. Treatment should be supervised by a pediatrician who will calculate the dosage based on the child's weight and age.

For the treatment of candidiasis localized in the oral cavity in young children and newborns, doctors recommend using Candide solution. It is gently applied to the mucous membrane and tongue using a cotton swab. Candide in solution form helps to get rid of the formed white plaques on the oral mucosa. During treatment, personal hygiene, handling of nipples, toys and bottles is of great importance.

Instructions for use

Before applying the drug, you should thoroughly wash your hands with soap and water;
Rinse the affected skin area with running water room temperature;
A single dose for external use - a 5 mm strip of the product on an area of \u200b\u200b75-100 cm 2 of the affected skin;
The medication is used only as directed by a doctor 2 to 3 times a day;
A therapeutic course for the treatment of skin mycoses lasts on average 1 month. For nail fungus Candide is used for 3-4 months;
The drug is applied not only until the clinical symptoms disappear completely, since 100% destruction of the fungal infection occurs after 2 weeks;
When applying Candide cream, you need to pay attention to hard-to-reach places, in particular, interdigital spaces;
For complicated candidiasis infections, the doctor must choose a comprehensive treatment using various dosage forms.

special instructions

When treating a fungal infection of the external genital organs in men and women, it is necessary to simultaneously treat the sexual partner. This tactic will prevent re-infection with a pathogenic fungus. In both long and short courses, patients who are newly infected with genital candidiasis respond better to treatment than patients with a history of fungal infection. After an acute episode has been treated, further prophylaxis (supportive care) is important. Patients are more likely to adhere to the drug regimen when antifungal therapy is given orally, but oral treatment carries a greater potential for systemic toxicity and drug interactions.

The instructions for use say that it is better not to apply the drug if the integrity of the skin and mucous membranes is broken.

If clinical improvement does not occur after 4 weeks of treatment, it is necessary to conduct additional diagnostics and revise the diagnosis. Some infections (especially skin and toenail infections) require up to 8 weeks of therapy to heal completely.

Preparations containing clotrimazole in fixed combination with betamethasone dipropionate are not recommended for the treatment of diaper dermatitis.

Analogs

Other antimycotics also target the ergosterol biosynthetic pathway, despite being considered chemically distinct from clotrimazole or azole compounds in general. In particular, allylamines, including terbinafine, inhibit the enzyme squalene epoxidase, which previously acts on the biosynthetic pathway of ergosterol. These compounds are fungicidal and also active against filamentous fungi and several pathogenic yeasts.

Candide can be administered in combination with azole drugs to achieve a synergistic inhibitory effect on ergosterol synthesis.

Analogs of Candide cream:

Clotrimaztol;
Clotrimazole ointment;
Nizoral;
Candiderm;
Kandibene;
Lotrimin;
Terbinafine;
Guiné-Lotrimin;
Candizol.

Reviews

Galina, 37 years old, Moscow: “I recently bought my child a little kitten at the collective farm market. Such happiness for a five-year-old daughter! But after a few days, spots appeared on her skin. Then I immediately realized that the kitten had infected my baby with shingles. We went to see a dermatologist at a private clinic and they prescribed Candide antifungal agent for children. Of course, I was interested in the safety of the medicine for the child and how much it costs. A good imported drug, available, absorbed well, practically odorless. Deprive we cured quickly enough. At the same time, we treated the kitten for lichen at the veterinarian. "

Larisa, 56 years old, Fryazino: “With the help of Candida, I treated my foot fungus. I noticed that in the summer, calluses, dry calluses and cracked heels are very often formed. I read on the internet that calluses are caused by a fungal infection. I bought a special file for heels. It is made from abrasive materials. After washing my feet with laundry soap, I treat them with a special scrub and remove corns with a file and smear with Candide. I did not immediately notice the effect of this cosmetic and medical procedure. Only after a month of my "labors" the skin on my legs became pink and smooth. Although at my age it is no longer possible to achieve perfect smoothness of the legs. "

Veronica, 44 years old, Tyumen: “After we visited the Mediterranean, in July I got some white spots on my face. But it didn't look like a pigmentation disorder. A dermatologist in our district clinic told me that these are manifestations of tinea versicolor and this often happens after visiting hot countries. She prescribed me an antifungal agent and told me to smear the spots on my face twice a day. I was cured in about 3 weeks. Although the spots themselves disappeared after about a week of treatment. The doctor advised me to apply it a little longer so that the disease does not come back. "

Valentina, 41 years old, Pushkino: “I ran into Candide when my son, at the age of three, had a fungus on his penis. This unpleasant situation arose after taking antibiotics for a week. The child did not sleep well, he was worried about itching. The foreskin was slightly red and swollen. At first, I decided to fight the infection with the help of folk remedies and put the child in a bath with chamomile and string. However, the infection did not go away. It seems to me that it got even worse. Most likely, another allergic component has joined. In general, after unsuccessful self-treatment, my son and I went to see a pediatrician. She redirected to a dermatologist, and the doctor advised me to buy this cream for the fungus. The drug is good, does not have a nasty smell, and its texture is delicate. I noticed the effect of the application after about 3 days. Were treated for a total of one week. "

Valeria, 45 years old, Pskov: “Candide for women was prescribed to me by a gynecologist for vulvovaginosis. I also bought antifungal suppositories and inserted them into the vagina. The itching is gone. The white and cheesy discharge also stopped. The doctor said that in order for the candidiasis not to return, it is necessary to treat her husband. I also bought him Candide for men. "

Conclusion

Candide cream is an effective antifungal agent that helps to get rid of infections in various areas of the skin and mucous membranes. The drug stops the development of a pathogenic fungus and eliminates the clinical symptoms of the disease. It almost completely destroys the mycelium and destroys the focus of inflammation. The medication can be prescribed for adults and children to treat fungal diseases.

Name:

Candid

Pharmacological
act:

Antifungal drug, which has a wide range of actions.
Active ingredient Candida - clotrimazole - is a derivative of imidazole. Its antifungal effect is due to a violation of the production of ergosterol, which is part of the fungal cell membrane. As a result of the action of clotrimazole, the permeability of the cell membrane changes, which leads to cell lysis. Small doses of the drug have a fungistatic effect, large doses have a fungicidal effect, including on non-proliferating cells. Fungicidal concentrations of clotrimazole are able to interact with peroxidase and mitochondrial enzymes, contributing to an increase in the concentration (up to a toxic level) of hydrogen peroxide, which, in turn, also leads to the death of fungal cells.

Candide active against mold, yeast-like fungi (Rhodoturola, Torulopsis, Candida) and dermatophytes (Microsporum, Epidermophyton, Trichophyton), the causative agent of erythrasma, tinea versicolor, as well as Aspergillus, Malassezia furfur, gram-positive bacteria (Staphylococcus spp., Corynebacterium minutissimum, Streptococcus Bpp.) And gram-negative (Gardnevaginalis spp. Vaginalis.
The absorption of clotrimazole with intravaginal administration is from 3 to 10% of the administered dose. For 48-72 hours, low concentrations of the drug in the blood and high concentrations in vaginal secretions remain. Clotrimazole to inactive metabolites is metabolized in the liver.

Indications for
application:

Candide used in therapy:

Mycosis of the nails;
- multi-colored lichen;
- dermatophytosis of the head, legs, body;
- skin candidiasis;
- candidal vulvitis;
- candidal paronychia;
- candidal balanitis;
- candidiasis of the anus and external genitals;
- erythrasma;
- fungal diaper dermatitis.

It is used in the treatment of genital infections caused by the fungi Candida or Trichomonas vaginalis, and genital superinfections caused by microorganisms sensitive to clotrimazole.
Candide is prescribed for the rehabilitation of the birth canal in preparation for childbirth.

Mode of application:

A small amount of lotion, gel, or cream rubbed into a dry and clean area affected skin 2-3 times a day. It is recommended to continue therapy with Candida after the disappearance of the symptoms of the disease for another 3-4 weeks to prevent relapses and complete mycological cure.
Candide in the form of a lotion (solution) recommended for use in case of extensive lesions of the skin and scalp.
Candide in the form of vaginal tablets injected deeply, intravaginally, in the supine position, with bent legs. Candide is prescribed once at bedtime, 500 mg.
When using Candida to sanitize the birth canal, it is enough to inject 500 mg of the drug (1 tablet) once.

special instructions

To prevent urogenital reinfection, simultaneous treatment of sexual partners is necessary.

In case of trichomoniasis, for more successful treatment, other drugs with a systemic effect (for example, oral metronidazole) should be used in conjunction with Candide.

With a simultaneous infection of the labia and adjacent areas (vulvitis candidiasis), additional local treatment with Candide cream should be carried out.

During pregnancy, treatment with vaginal tablets should be carried out without an applicator.

In patients with hepatic insufficiency, the functional state of the liver should be monitored periodically.

If signs of hypersensitivity or irritation appear, treatment is discontinued.

If there is no effect within 4 weeks, the diagnosis should be confirmed.

Side effects:

For outdoor use In rare cases, candida occurs with local irritation that disappears on its own with continued treatment.

With intravaginal use Candida may experience burning, itching, vaginal discharge, edema of the vaginal mucosa, headache, frequent urination, gastralgia, intercurrent cystitis, pain during intercourse, burning sensation in the partner's penis.

Contraindications:

- specific skin lesions (including tuberculosis, chickenpox, herpes simplex, measles, syphilis);
- skin reactions at the vaccination site;
- hypersensitivity to drug components.
- I trimester of pregnancy;
- period of menstruation.

Carefully:
- period breastfeeding.

Interaction
other medicinal
by means of:

With vaginal administration clotrimazole reduces the activity of amphotericin B and other polyene antibiotics. With simultaneous use with nystatin the activity of clotrimazole may decrease.

Pregnancy:

In clinical and experimental research not foundthat the use of the drug during pregnancy or breastfeeding has a negative effect on the health of a woman or fetus (child). However, the question of the advisability of prescribing the drug should be decided individually after consulting a doctor.

Overdose:

The use of the drug in high doses does not cause any reactions and conditions that are life-threatening.

Symptoms (in case of unintended use of the drug inside): anorexia, nausea, vomiting, gastralgia, liver dysfunction; rarely - drowsiness, hallucinations, pollakiuria, allergic skin reactions.

Treatment: the appointment of activated carbon, if necessary - symptomatic therapy; there is no specific antidote. in 20 g aluminum tubes; in a pack of cardboard 1 tube.

Candide Solution for external applications 1%:

in plastic bottles of 20 ml, in a cardboard box 1 bottle.

Candide Powder for outdoor application of 1% white, with a characteristic odor.
1 g of powder contains 10 mg of clotrimazole;
in plastic bottles of 30 g, in a cardboard box 1 bottle.

Candide Solution for local application 1% colorless, transparent, viscous.
1 ml of solution contains 10 mg clotrimazole;
excipients: propylene glycol - 495 mg; glycerin - 495 mg;
in dropper bottles of 15 ml, in a cardboard box 1 bottle

In this medical article, you can read the drug Candide. The instructions for use will explain in which cases you can take a cream, gel, solution or tablets, what the medicine helps from, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can leave only real reviews about Candide, from which you can find out whether the medicine helped in the treatment of candidiasis (thrush) and other types of mycoses in adults and children, for which it is also prescribed. The instructions list Candida analogues, drug prices in pharmacies, as well as its use during pregnancy.

A synthetic broad-spectrum antifungal drug is Candide. Instructions for use indicate that vaginal tablets or suppositories 500 mg, cream 1%, gel 2%, solution 1% are used to treat fungal infections of the mucous membranes and skin.

Release form and composition

The drug is produced in the following dosage forms:

gel Candide 2%;
powder for external use 1%;
vaginal tablets (suppositories) Candide;
solution for topical application 1%;
cream for external use 1%;
Candid B6 - vaginal tablets 100 mg (analogue of suppositories);
Candide B is a cream for external use.

The cream is a homogeneous white substance contained in a 20 g aluminum tube.

The cream contains the active ingredient clotrimazole, as well as auxiliary components: white petrolatum, propylene glycol, emulsion cetomacrogol wax, liquid paraffin, butyl hydroxytoluene, propyl parahydroxybenzoate, methyl parahydroxybenzoate, benzyl alcohol, sodium hydrogen phosphate, sodium dihydrate.

Solution for topical application, transparent, colorless, has a viscous consistency. The bottle contains 15 g of the product. The Candide solution contains the active ingredient clotrimazole, as well as glycerol and propylene glycol as additional components.

Powder for external use (dusting) is contained in a plastic bottle of 30 g. Instructions are included in the box with the preparation.

pharmachologic effect

Candide tablets, vaginal gel, powder, solution and cream are antifungal drugs widely used in the treatment of various candidal diseases. The active ingredient of this product perfectly penetrates into all layers of the skin, destroying bacterial cells.

The active ingredient of the drug (clotrimazole) has a detrimental effect on yeast, yeast-like and mold fungi (Candida, Torulopsis, Rhodoturola), some strains of gram-positive and gram-negative microorganisms (Gardnerella vaginalis, Corynebacterium minutcus spp., Stuccus spp. (Epidermophyton, Trichophyton, Microsporum).

Indications for use

What does Candide help with? The drug is used if the patient has the following diseases or symptoms:

candidal vulvitis;
candidal paronychia;
erythrasma;
candidal balanitis;
candidiasis of the skin;
mycoses of feet and skin folds;
superficial candidiasis, which cause yeast, mold and other fungi, dermatophytes, as well as a number of other pathogens demonstrating sensitivity to clotrimazole;
mycoses, in which there is a complication of secondary pyoderma;
fungal diaper dermatitis;
candidiasis of the anus and external genitals;
pityriasis versicolor, versicolor versicolor.

Solution Candide for the oral cavity is used for stomatitis of candidal origin.

Vaginal tablets are used to treat genital infections, as well as genital superinfections provoked by microorganisms sensitive to clotrimazole.

Candide is also used to sanitize the birth canal during preparation for childbirth.

Candide vaginal tablets or suppositories

It is inserted intravaginally, deeply, in the supine position with slightly bent legs. 500 mg once (in the evening). A second course of treatment is possible after consulting a doctor. For the rehabilitation of the birth canal, a single administration of 1 table is recommended.

Instructions for the use of Candide solution for children

To treat the oral cavity from fungus for children, only Candide 1% solution for local use is used. In no case should you use a solution for external use. These are two drugs with completely different effects on the mucous membranes. In the instructions for use of the drug, Candide solution indicates that 10 - 15 drops of the agent are applied to a cotton swab, which then treats all mucous membranes of the oral cavity. Treatment of the oral cavity is carried out 2 to 3 times a day after the child has eaten. You must first remove white plaque from the mucous membranes.

Galina Kiryunina: “By this folk remedy I have defeated the MILK MAKER forever You just need ... "

The effectiveness of the use of Candida from thrush in children is noticeable as early as 2-3 days, since the drug stops the growth of the fungus in the oral cavity. The advantage of the drug is that it acts exclusively locally, so it does not enter the bloodstream. Candide drops for children may be contraindicated for those who have an increased sensitivity to clotrimazole, which is the active ingredient of the drug, or to any substance that is part of the drug. Side effects in the treatment of the oral cavity with a solution may include:

Burning in the mouth
Bad taste
Nausea if the drug gets into the throat

At what age can children be used, treatment features

Over the past decades, invasive fungal infections, which have become a leading cause of illness and death, especially in people with weakened immune systems. One of the reasons for the noticeable increase in the number of these problem infections is the increase in the number of patients with immunosuppressive conditions.

Candide ointment is considered to be an effective, safe and well-tolerated drug with an unusual chemical composition... It is widely used in the treatment of thrush, skin, vulvovaginal and oropharyngeal fungal infections.

The drug's minor side effects and uncomplicated metabolic profile have earned it worldwide acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections and fungal infections of the skin and nails. Due to its usefulness, clotrimazole is included in the list of essential medicines by the World Health Organization.

Skin infections caused by candida or dermatophytes can be effectively treated with topical clotrimazole.

Candide in the form of a cream is well tolerated and does not cause undesirable reactions in patients.

Instructions for using Candide cream:

Before using Candide cream, wash your hands thoroughly with soap and water;
Rinse the affected area with running water at room temperature;
Apply antifungal cream with an even thin layer;
The medication is used only as directed by a doctor, the dosage regimen is 2-3 times a day;
The therapeutic course lasts on average 1 month;
The medication is applied not only until the clinical symptoms disappear completely, since 100% destruction of the fungal infection occurs after 2 weeks;
When applying Candide cream, you need to pay attention to hard-to-reach places, in particular, interdigital spaces;
For complicated candidiasis infections, the doctor must choose a comprehensive treatment using various dosage forms.

Children of preschool and primary school age can use Candide cream in exceptional cases when it is necessary to get rid of the fungus on the skin. Dosage forms intended for intravaginal use are prohibited for children under 12 years of age. The drug is completely contraindicated for children under 3 years of age.

How to identify oral candidiasis

To confirm the diagnosis, it is enough to take a swab from the oral mucosa and send it to the microbiological laboratory, which will sow the mushrooms. If necessary, referral to EGD to confirm or exclude the diagnosis of esophageal candidiasis.

Thus, if worried about:

Itching, pain in the mouth;
When examining the mouth - whitish overlays or curdled masses or dense plaque, when trying to remove which the mucous membrane begins to bleed, then the diagnosis of oral candidiasis is likely.

See a doctor if possible.

If it is not possible to get an appointment with a doctor, then buy a solution for the oral cavity "Candide" and, without delay, start treatment. After a couple of days, your health should improve significantly. If there is no effect of the treatment, consult a doctor.

And after recovery, lead a healthy lifestyle, keep your hands clean, spend more time in the fresh air, take multivitamins in spring and autumn.

The action of the drug Candide B with a fungus

Candide B is an antifungal medication that is widely used in dermatology, gynecology and other fields of medicine. The drug is characterized by high efficiency and quick results.

Candide b hormonal or not

The drug contains a glucocorticosteroid - beclomethasone, which means that the drug belongs to hormonal.

Method of administration and dosage

The cream is intended for external use. It should be applied to clean and dry damaged areas of the dermis.

It is necessary to carry out medical manipulations 2-3 times a day. Rub in the ointment with light massage movements and leave until absorbed.

Candidiasis therapy should last 2-4 weeks after elimination of all clinical symptoms of the pathology in order to ensure mycological cure and prevent recurrence of the disease.

Candide b with thrush in women

For the treatment of thrush in women, Candide B6 is used, which is produced in the form of vaginal suppositories. They are effective for fungal genital infections, the development of which was influenced by yeast-like fungi of the genus Candida or Trichonoma vaginalis. It is necessary to use candles once a day for 2 weeks.

In pediatrics, the drug is not widely used, therefore, children have no experience of using the drug. Prolonged use of the medication in a child may lead to an increased risk of adrenal suppression.

During pregnancy lactation

During the period of bearing a child and HB, the drug is not used. It can be prescribed only if the possible benefit to the woman's body outweighs the potential harm to the fetus or baby.

The intravaginal form of the medication is prohibited for use in the 1st trimester of pregnancy. A high dose of clotrimazole leads to the development of embryotoxic effects. There is no information about whether the active substance is excreted in breast milk.

Side effects

The considered drug, subject to the dosage, is well tolerated. But with prolonged therapy, the development of side symptoms is possible:

allergies, redness of the skin and mucous membranes;
burning and tingling sensation in the area of \u200b\u200bapplication of the cream;
urticaria, erythema;
itching, blistering;
swelling, irritation of the vaginal mucosa and peeling.

With the development of such symptoms, therapy with Candide B should be discontinued.

Interaction with other medications and alcohol

Taking the drug together with Amphotericin B, Nystatin will reduce the effect of clotrimazole. A combination of a medication with systemic antibacterial and antimicrobial agents, as well as with forms for external and intravaginal use, is allowed. Before combining Candide with other drugs, you should consult your doctor.

Special instructions for use

The drug is allowed to be used only in the treatment of dermatological pathologies. If you use the cream as part of the complex therapy of candidiasis in the anogenital areas, then you can milk the expressed positive results and the patient's recovery.

If glucocorticoids are used on large areas of the skin or if occlusive dressings are used, this can lead to systemic absorption of the drug. Symptoms such as pyoderma, folliculitis, or a rash may also develop.

Conditions of release and storage

It is necessary to keep the medication in a place where there is no light, there is no access for children, and the temperature is not higher than 25 ° C. It is necessary to use the tool within 3 years from the date of issue.

Pharmacodynamics

All azole-type antifungals interfere with the biosynthesis of ergosterol, which is considered the main component of the fungal cytoplasmic membrane.

Ergosterol performs a function similar to cholesterol in animal cell membranes.

The effect of the drug is due to its interference with the biochemistry of the fungal cell

Clotrimazole disrupts the synthesis of a vital fungal cell protein that is not found in the human body. Depending on the dose, the drug either disrupts the reproduction of fungi or causes their death

For humans, Candide cream is safe - the protein it affects is not produced in the human body.

The drug is effective against the following types of fungi:

dermatophytes;
mold fungi;
yeast-like mushrooms;
pathogens of varicolored lichen and erythrasma.

There is moderate activity against staphylococci and streptococci. This avoids bacterial complications during treatment.

Candid B instructions for use, dosage and method

Drug overdose is unlikely. When used correctly, it almost never occurs. If the cream is applied to the mucous membrane of the vagina or the glans of the penis, absorption occurs somewhat faster, but cases of overdose were also not recorded.

In case of an overdose of beclomethasone (usually as a result of prolonged use on large skin areas, especially with impaired integrity, as well as in the case of prolonged use in children), undesirable adverse reactionsassociated with insufficient function of the adrenal cortex and suppression of their function.

Treatment consists in the abolition of Candida B and the appointment of the necessary symptomatic therapy.

Description of Candide cream ointment and its use for nail fungus

Price

In the Moscow region - from 100 to 1000 rubles.
In St. Petersburg - from 60 to 700 rubles.
In other regions of Russia, the price is slightly lower.

The cost of the product depends on the region, the form of release and the pharmacy where they buy.

Where can I buy

The drug is quite widespread in city pharmacies. Links to online pharmacies:

apteka.ru.
rigla.ru.
apteka-ifk.ru.

Sold without a prescription.

Release form

Ointment Candide is available in the form:

Creams.
Solution (drops).
Dry powder.
Pills.
Gel.

What to choose

The cream is more suitable for the treatment of periungual skin and cuticles.

To get rid of nail fungus (onychomycosis), it is better to choose a solution and tablets for combination therapy.

Composition of the preparation

1 g of ointment contains:

Clotrimazole. The active ingredient, a synthetic antifungal agent, is widely used in pharmaceuticals to arrest and kill most known fungi.
Vaseline, paraffin. The basis for the ointment.
Propylparaben. Plays the role of a preservative.
Emulsion wax. Plays the role of an emulsifier.
Butylhydroxytoluene. Substance based on phenol. Added to the composition due to its good antioxidant properties.
Methylparaben. An effective preservative, it is also a powerful antiseptic and has a good antifungal effect.
Alcohol and water.

Analogs

Candida has several analogs, they have similar effects, but still differ:

Triderm - requires more frequent application, because it is quickly absorbed. Does not leave marks on clothes.
Akriderm GK - has not only an antifungal effect, but also helps with allergic reactions or inflammatory skin lesions.
Other clotrimazole ointments.

Cheap analogues

Kanesten - 128 rubles. (20 g).
Clotrimazole - 60 rubles. (20 g). It is part of Candida, as the main active ingredient, but it is also produced separately without excipients.

Properties of the drug

The ointment has antiprotozoal and antibacterial properties. Thanks to this, it is effective against:

Erythrasmus;
Depriving;
Mycosis;
Onychomycosis;
Thrush.

How does

The action of the ointment is based on damage to the walls of fungal cells. This leads to a halt in their development. The disease remains on the nail, but stops spreading, so the full treatment lasts until the new nail grows back.

Instructions for use

Candida has a shelf life of 4 years. Store the ointment in a dark place, where the temperature should not exceed 25 ° C. Hide from children.

Official instructions (263 KB).

Mode of application

Before using the ointment, the affected area should be washed with soap and dried. Then apply the product in a thin layer and rub well into the sore spot. Repeat the procedure until complete recovery.

Dosage

It is best to apply the ointment in a thin layer and do not overdo it. However, if you smear it uncontrollably, there will be no serious consequences associated with an overdose. In this regard, Candide is safe if there are no contraindications.

Features of use with other drugs

If used together with a remedy such as Nystanin, the effect will be significantly reduced and the use will be much less effective. If the patient takes antibiotics, the effect will be exactly the same.

Contraindications

The drug should not be used by a nursing woman or in the first trimester of pregnancy. Irreversible consequences for the developing fetus are possible. An individual contraindication is an allergy to the components of the ointment.

Side effects

Hives.
Redness formation on the skin.
Peeling.
Edema.
Severe allergic reaction to the composition of the product.

If this happens, you should immediately contact the doctor who prescribed the drug, as standard treatments for side effects may not be effective.

Pros and cons of the remedy

Positive:

Low price;
A small list of contraindications.

Negative sides:

Some people may have side effects.

Video review of a remedy from a doctor:

special instructions

With the simultaneous appointment of Candide cream and nystatin, the effectiveness of Candide may decrease.

After an acute episode has been treated, follow-up prophylaxis (supportive care) is important. Patients are more likely to adhere to the drug regimen when antifungal therapy is given orally, but oral treatment carries a greater potential for systemic toxicity and drug interactions.

It is better not to apply the drug if the integrity of the skin and mucous membranes is broken.

The effect of the drug on pregnant and lactating women is not fully understood. The use of Candide cream during the period of gestation and when feeding him is not recommended.

Preparations containing clotrimazole in fixed combination with betamethasone dipropionate are not recommended for the treatment of diaper dermatitis.

The instructions for use recommend using Candide ointment strictly for local treatment - application to the affected area of \u200b\u200bthe skin. Special dosage forms in the form of vaginal tablets and gel are intended exclusively for use in the vagina, the gel can be applied to the mucous membrane of the penis.

The oral solution can be used only for the treatment and prevention of candidal stomatitis. It is not allowed to use drugs in an inappropriate way The instruction also recommends that you be attentive to age restrictions, observe the dosage regimen and recommendations of the attending physician in order to effectively cure the disease and avoid complications.

If you experience any unpleasant symptoms associated with treatment, you should consult a doctor. If it becomes necessary to use any other drug together with Candide, you should consult a specialist about drug compatibility.

If possible, long-term treatment should be avoided, especially in childhood (due to the risk of suppressing the function of the adrenal cortex). When used in large areas of the body, beclomethasone may be absorbed into the systemic circulation.

The cream should not be applied to mucous membranes and the area around the eyes. Contact with eyes must be avoided.

If infection develops or spreads, Candide B must be canceled and appropriate antimicrobial treatment prescribed.

Bacteria thrive in warm, humid conditions, so the skin should be thoroughly cleansed and dried before applying the drug.

There are no data on the negative effect of Candide B cream on the patient's ability to drive vehicles or other mechanisms.

Instructions for use:

Candide is a synthetic broad-spectrum antifungal drug used to treat fungal infections of the skin and mucous membranes.

pharmachologic effect

Candide, as an antifungal drug, is widely used to treat various candidal diseases, penetrating well into various skin layers and destroying bacterial cells.

The active ingredient is active against many yeast-like, mold and yeast fungi (Torulopsis, Candida, Rhodoturola), dermatophytes (Trichophyton, Epidermophyton, Microsporum), and some strains of gram-negative and gram-positive bacteria (Streptococcus spp., Stbacim. ., Gardnerella vaginalis).

Release form

The drug is released in the form of a solution and cream for external use:

1% Candida solution - in the form of a viscous colorless transparent liquid. 1 ml contains 10 mg of active ingredient clotrimazole. The auxiliary substance is propylene glycol. In polyethylene bottles of 20 ml;
1% homogeneous white cream Candide. 1 g of cream contains 10 mg of active ingredient clotrimazole. Excipients - liquid paraffin, propylene glycol, emulsion wax, white petrolatum, methylparaben, alcohol, sodium phosphate anhydrous, propylparaben, sodium dihydrogen phosphate, butylhydroxytoluene and purified water. In aluminum tubes of 20 g.

Also Candide is released in the form of vaginal tablets. Each tablet contains 500 mg of the active ingredient clotrimazole.

Indications for the use of Candida

According to the instructions, Kandid is used when

Skin candidiasis;
Candidal vulvitis;
Candidal balanitis;
Epidermophytosis;
Stomatitis;
Candidal paronychia;
Candidiasis of the external genital organs and anorectal region;
Trichophytosis;
Mycosis of the nails;
Dermatophyte of the face, body, legs;
Interdigital fungal erosion;
Multi-colored lichen;
Fungal diaper dermatitis;
Erythrasme;
Dermatomycosis;
Microsporia.

Also, according to the instructions, Candide is used to sanitize the birth canal before childbirth.

Contraindications

The drug is contraindicated in case of hypersensitivity to active substance - clotrimazole. It is also contraindicated to use Candide ointment during menstruation and in the first trimester of pregnancy.

When prescribing the drug during breastfeeding, care must be taken.

Ointment and solution Candide should not be used on skin areas with violations of the integrity of the skin.

Instructions for the use of Candida

Ointment Candide, as well as Candide solution, is applied in a small amount to the affected skin areas, previously washed and dried, and rubbed in.

The treatment is quite long and should be continued for 2 to 4 weeks after the symptoms disappear to prevent relapse.

Solution Candide is used on hairy skin areas and with a large lesion area.

Candide in the form of vaginal tablets is prescribed at bedtime, 500 mg once. Also, one 500 mg tablet is enough to sanitize the birth canal. The drug is injected intravaginally, deeply.

Side effects

Solution and cream Candide rarely causes side effects in the form of local irritation, which usually goes away on its own.

When using Candida in the form of vaginal tablets, itching, burning, swelling of the vaginal mucosa, vaginal discharge, frequent urination or headache may occur.

According to the instructions, Candide, when used simultaneously with nystatin, amphotericin B and natamycin, reduces its activity.

The safety of using Candida during pregnancy and lactation has not been studied. Therefore, it is not recommended to prescribe the drug in the first trimester of pregnancy, as well as in high doses, on large areas of the skin and to carry out treatment for a long time.

Storage conditions

Candide is approved for over-the-counter leave. Shelf life of tablets and solution is 3 years, Candide cream is 2 years.