Found drugs with antiandrogenic action. Antagonism of human state hormones (antiandrogens). The mechanism of action of antiandrogenic OCs

As edited by this article, we open a series of articles Pro et contra (For and against, lat.). Our life is no longer the same. The ultimate law of dialectics affirms that “the basis of any development is the struggle (interaction) of protracted, mutually exclusive sides and tendencies that are currently occurring in the internal unity and each other "Emopenetrating."

In the human body, androgens and antiandrogens, estrogens and antiestrogens, gonadotropins and antigonadotropins, prostaglandins and antiprostaglandins interact peacefully and interact... In many of these words, it is possible to successfully establish the understanding of a doctor. any drugs.

Pro et contra.

M. V. Mayorov, obstetrician-gynecologist of the highest category, member of the National Council of Journalists of Ukraine (women's consultation at the Moscow Polyclinic No. 5, Kharkov)

Sapiens nil affirmat, quod non probet (“The wise man confirms nothing without proof”, lat.)

As far back as 1849. Bertholg confirms that the legacy of castration in the penis is evident during reimplantation of the removed testicles. In this way, I fell asleep in scientific endocrinology. Sensational tracks “on your own”, staged in 1889. Brown - Sequard, were introduced into the rejuvenating process by introducing bicus extract. Only in 1935, the work of David, Laqueu, Ruzicka succeeded in establishing the structure of testosterone and creating its synthesis.

Apparently, state hormones, steroids and androgens, play an important role in the vitality of the body. They ensure human statistic differentiation (formation of a similar morphotype, voice timbre, etc.), and indicate a specific function of the testicles, prostate, and seminal cells in humans.

Previously, robots have discovered that androgen receptors are present in many organs in men and women, and they also indicate a delay in the activity of these hormones. Thus, their role in mature bone tissue, regulation of the secretion of gonadotropins and the synthesis of lipids of various strengths, vibrobled endorphins, growth factors, and insulin are shown. Along with the anabolic effect, androgens regulate libido and sexual potency, stimulate the function of sebaceous glands and hair follicles. At physiological concentrations, androgens take part in the mechanism of follicular regression in the ovaries and cause the growth of hair on the pubis and inguinal recesses. With increased production of androgens and changes in their balance in both active fractions, signs of defeminization (reversal development of female organs) and lead to masculinization (development of tin state signs).

Often erased forms of hyperandrogenism (HA) play an important role in the genesis of infertility, anovulation, and unborn gestation in women. To ensure the correct approaches to diagnosis and treatment of conditions associated with increased production or activity of androgens, a practical physician needs to understand the main pathways of androgen metabolism in normal conditions and in pathology ( Rogovska S.I., 2000).

Table:: Classification of androgens from physiological action

Androgen receptor blockers	Features that influence the secretion, transport and metabolism of androgens
Simple (“pure”) antiandrogens (flutamide, AA 560, cyproterone, etc.)	Blockers of biosynthesis and secretion of hypothalamic releasing hormones and pituitary gonadotropins (progestins, estrogens)
Combined antiandrogens that block RA and may also have antigonadotropic and anti-5-β-reductase activity (similar to progestins and androgens)	Androgen biosynthesis inhibitors (aminoglutethemide, estrogens, etc.) 5-β-reductase inhibitors (estrogens, progestins, etc.) PSSG synthesis stimulators (estrogens, thyroid hormones)

The concept of “metabolism of androgens” means how they are transformed, and the nature of their connection with transport proteins in the blood, and cause the peripheral effect of various fractions of androgens in target organs. The frequent correlation between clinical manifestations and the level of androgen secretion can be explained by a change in the balance between fractions, as well as different sensitivity of receptors in target organs and different cells There are these receptors.

From the academic course of biochemistry it is known that the production of androgens and cholesterol in women is caused by the ovaries, epithelial glands and a number of similar reactions in other organs (accretion in the liver, skin, fats and meat tissues). In addition to the human, in the female body, the process of converting the different fractions of androgens into one is very difficult to integrate, the fragments of which can act as intermediaries for the synthesis of other natural steroids - progesterone and estrogens. For example, testosterone (T), dihydrotestosterone (DHT), androstenediol, androstenedione, dihydroepiandrosterone (DHEA) and dihydroepiandrosterone sulfate (DHEAS) can be detected as intermediate products in various organs.

One of the most active androgens - testosterone - is produced by other pathways. It is important that in healthy women, 50-70% testosterone is achieved through peripheral conversion to androstenedione; I decide to produce ovaries and overlying vines.

Instead of testosterone in the blood, the active stage of androgenization may not be present, since the bulk of androgens are present in the plasma in the associated state, rendering them inactive. Approximately 20% of them are associated with albumins, 78% with globulins. The most stable binding is ensured by the use of statistic steroids – binding globulins (BSG), the synthesis of which occurs in the liver. Only a small portion of testosterone (1.6%) is no longer potent and active. It is important that the level of high-quality testosterone is an informative indicator of androgenicity, the lower level of which is related, because of its significance, the evidence of special technologies and in widespread practice stagnates until sit rarely.

The value of testosterone is sufficiently adequate test available in any clinic. The concentration of PSSH in women is twice as high as in men, and its synthesis is stimulated by estrogens. It has been established that in women with GA the concentration of PSSH is often lower than in healthy women.

In pathological conditions that lead to androgenization, there is not only significant disruption in the synthesis of hormones, but also a clear change in the importance of metabolites, which may result in power imbalances. In addition, physiological reactions to excess androgens vary in different individuals and depend on a variety of factors. Over the past decade, the existence of specific receptors in target organs has been established. Cytosolic RAs, which are proteins of the song structure, appear in a number of organs (meat and cystic tissue, skin, sebaceous glands, pituitary gland, hypothalamus, etc.) and are subject to the influx of anonymity circulating androgen metabolites, which are found in the cytoplasm via passive diffusion. The function of the receptor is that it is responsible for recognizing its hormone, combining with it into a single complex, entering the nucleus and ensuring a specific response. This process is highly complex and rich in components. It is important that RA in the female body is stimulated by estrogens.

Clinical manifestations of androgenization

Severe disruption of androgen metabolism results in the appearance of a wide range of clinical symptoms, which is attributed to the cause of pathological changes and illness. These manifestations include virilization and anabolization and, being expressed, do not, as a rule, become particularly difficult for diagnosis. However, in gynecological practice, doctors have to deal with symptoms of acquired androgenization, such as anovulation, amenorrhea, uterine hypoplasia and mammary tract, alopecia, acne, oily seborrhea, hirsutism, etc. human type (creatures, flank, back).

Pathogenetically, hirsutism is inherited by increased production of androgens, increased activity of the skin 5-β-reductase enzyme, which promotes the conversion of T from DHT, as well as increased sensitivity of target organ receptors to androgens . With increased sensitivity of skin receptors to androgens, idiopathic hirsutism develops, which is not necessarily accompanied by HA. The general idea is that 30% of the female population may have some level of hirsutism, and 10% will require diagnosis and treatment.

Clinical manifestations of androgenization and further treatment are determined by reasons, mainly: genetic (for example, race, family); physiological (for example, in athletes); post-traumatic; iatrogenic (for example, in newborns - after taking mothers during pregnancy and androgenic drugs); nadnirkov; ovarian; hypothalamic-pituitary; genetic chromosomal abnormalities; hypothyroidism

Differential diagnosis depends on the subsequent exclusion of these and other causes and can be carried out at the initial stage by an endocrinologist. The supraneural and ovarian forms of HA are most often encountered in the practice of an obstetrician-gynecologist.

Supernadir forms of hyperandrogenism are mentally divided into primary and secondary. To the primary ones, one can add hyperplasia of the measles of the supra-nirvania and the swelling of the supra-nirvana.

The pathology of adrenal glands most often manifests itself in the form of adrenogenital syndrome (AGS), if there is an inferiority of enzyme systems, which leads to a decrease in the production of cortisol. Depending on a specific biochemical defect, which causes a lack of cortisol, there are 5 groups of hyperplasia, if there are defects in 20-22-desmolase, 3-ol-dehydrogenase, 21-hydroxylase (21 HO), 11-hydroxylase, 17-hydroxylase. It has now been discovered that the main cause of AGS is a congenital, genetically determined illness associated with an autosomal recessive gene (on the short arm of chromosome 6). In 80-90% of patients, the inferiority of enzyme systems manifests itself in the appearance of 21-hydroxyl deficiency with further decreases in normal products of steroidogenesis (mainly cortisol), which leads to an increase in ACTH, which stimulates the synthesis of androgen-active substances. no cortisol until level 17 - oxyproge reduces the development of hyperplasia measles and further increased production of androgens.

Viral forms of AGS become more frequent and are mentally divided into congenital and “meaty” (later). The native form is accompanied by signs of pseudohermaphroditism, the diagnosis is primarily established in the population. It is much more important to identify latent forms of AGS, especially latent forms. In the pubertal form of late AHS, clinical symptoms appear during the period of maturation, and in the postpubertal form - later, at different periods of the woman’s life. It is important that what are called “soft” forms of AHS, if the deficiency of 21-hydroxylase is minor, is often associated with secondary polycystic ovaries (PCOS).

The diagnostic criteria for the hyperfunction of the measles of the supraneural glands are far from always unambiguous, and the differential diagnosis is often very complicated, despite the literature data, it is possible to point out certain signs, which are most often obvious They are desperate for practice.

Main diagnostic criteria for supernadir GA(Rogovska S.I., 2000): characteristic anamnesis (slackness, late menarche, impaired menstrual function after menarche, infertility, non-pregnancy); a specific morphotype with significant hirsutism, hypoplasia of the body organs and mammary glands, weak development of the subcutaneous fat ball; results of fasting (anovulation, amenorrhea, inferiority of the luteal phase to the cycle, etc.); laboratory data and test results (high 17-KS, DGEAS, DHEA, T, 17?-hydroprogesterone, positive test with dexamethasone and ACTH); early closure of growth zones based on radiographic follow-up data.

Puffy tissues of supra-neural hosts (glucosterome, glucoandrosterome) also show clinical manifestations of virilization. The appearance of swelling is often characterized by a rapid growth and rapid progression. The diagnosis is made based on ultrasound data, computed tomography and hormonal tests (high levels of DDA, T and 17-KS do not decrease after a test with dexamethasone).

Secondary hyperandrogenism supraneural genesis is detected in other types of neuroendocrine pathology: hypothalamic-pituitary syndrome of advanced maturation, Etsenka-Cushing's disease, acromegaly, etc.

Hypothalamic-pituitary syndrome during the period of maturation(GSPPS) is a symptom complex of polyglandular dysfunction with impaired metabolic and trophic processes, disorders of the cardiovascular and nervous systems, and impaired menstrual function. GSPS is most often characterized by a singing morphotype, tall stature, obesity in the appearance of the apron and in the shoulder girdle, the presence of striae, hyperpigmentation and marmurous skin, overproduction of glucocorticosteroids Eating and androgens. In case of Etsenka-Cushing's illness, the hypothalamic-pituitary structures are primarily affected, which leads to secondary hyperfunction of the supraperebral cortex. The most common symptoms: obesity, flatulence, inhibition of growth and development of the body due to premature hair loss, acne, impaired speech metabolism, asymmetry of tendon reflexes. In Itsenko-Cushing syndrome, clinical manifestations lie in the cause of the syndrome, which is often accompanied by persistent hypertension, disorders of the cardiovascular system, obesity, and osteoporosis.

Ovarian forms of GA

Increased production of androgens by the ovaries is avoided in PCOS, hyperthecosis, and other types of swelling. The nutritional etiology and pathogenesis of PCOS has been a difficult time and will be deprived of dietary supplements. Nina’s illness is perceived as a polyglandular, polyetiological, polysymptomatic pathology. Most authors respect the ability to clearly see the primary and secondary forms.

The primary PCOS is responsible for promoting the secretion of androgens in the ovaries through disruption of the processes of aromatization of steroids, sedation, and deficiency of 17-β-hydroxysterodehydrogenase. Side effects of PCOS can accompany a number of other pathological processes, such as inferiority of hypothalamic structures, hyperprolactinemia, AGS, SHBPS, changes in the reception of hormones in the periphery, etc.

Hypersecretion of androgens in PCOS is a process dependent on luteinizing hormone (LH). As the LH level increases, the LH/FSH index also changes due to an increase. Chronic hyperstimulation of LH is manifested by hyperplasia of the ovarian tissue. The synthesis of excess androgen occurs in small follicles that mature, not reaching 6 mm, because granulosa cells in them are not mature and aromatase activity does not appear in them. With a high level of testosterone, the peripheral production of estrogens increases, which is considered one of the reasons for the elevated level of LH in PCOS. A metabolic cycle is created that leads to anovulation, infertility and PCOS.

The work of the remaining researchers has established the active role of factors of growth and hyperproduction of insulin in the genesis of ovarian GA. It has been shown that growth hormone promotes the release of insulin-like growth factor (ILPGF) in granulosa cells, which in turn promotes the production of androgens by LH cells. Insulin reduces the proliferation of PSSG and promotes the level of testosterone that is resistant to insulin. Therefore, hyperproduction of androgens can be associated with the development of diabetes, so it is important to take care of patients with symptoms of androgenization. The diagnostic criteria for ovarian HA, as well as for supernasal HA, are also ambiguous, but these are most often the case.

Main diagnostic criteria for HA ovarian genesis: the appearance of amenorrhea or oligomenorrhea after a period of normal regular menstruation with the beginning of a stately life, or after stressful situations, and severe cramping occurs; female morphotype with moderately expressed hirsutism and obesity after the female type; enlargement of ovaries and PC according to ultrasound and laparoscopy, anovulation on the basis of aqueous and absolute hyperstrogenia; laboratory data and the results of hormonal tests (high level of testosterone, LH, movement index LH/FSH, hyperprolactinemia, positive hCG test etc.).

Morphologically, PCOS is differentiated from a rare disease called hypertecus, if the ovaries contain no islands of hyperplastic luteinized cells of the superficial ovarian stroma. Clinical diagnosis is important (most often it manifests itself as acne, hirsutism, clitoral hyperplasia; among hormonal studies, it is most likely to reveal a high level of testosterone with low concentrations of gonadotropes niv).

Therapy

Treatment of illness, which is accompanied by symptoms of androgenization in women, is determined by the type of pathology, the localization of the process, the degree of severity, and may also be complex. Etiopathogenetic therapy includes removal of puffiness, administration of iatrogenic fluid, suppression of stimulated androgen synthesis, treatment of Cushing's syndrome and disease, hypothyroidism, resection or cauterization of the ovaries, administration of drugs with antiandrogenic action. on target organs with cosmetic procedures and psychological support. The most obvious use of pathogenetic therapy can be seen in the use of glucocorticoids (dexamethasone, prednisolone) in AHS, aimed at filling the cortisol deficiency and reducing the synthesis of androgens by the adrenals. However, an unknown part of therapy for erased and manifested symptoms of androgenization, practically any etiology, is the use of antiandrogens to reduce these symptoms.

Antiandrogens

To relieve the symptoms of androgenization, drugs called antiandrogens are used to prevent the synthesis of active androgens and the effect in target organs. They are used for signs of androgenization in women and for certain illnesses in men.

Based on the findings about the biodynamics of androgens in the body, the following ways of blocking androgenic influxes are theoretically transmitted: galvanization of the biosynthesis of androgens and the secretion of hormones in dogs; changes in gonadotropic stimulation (LH, FSH, ACTH); reducing the effects of androgen stimulation on target organs due to the blockade of RA in cells that respond; changes in the concentration of active fractions of androgens; promotion of PSSG products; accelerated metabolic inactivation of androgens and their elimination from the body.

Real results can be obtained through the complex influx of the process of androgenization, thereby ensuring a significant decrease in the level of active androgens that circulate in the blood, which is transferred to the established androgen-receptor complex.

The main meta-vikoristannya OK for GA- reduction in the synthesis of gonadotropins, galvanization of the proliferative effect of estrogens on the endometrium and normalization of the menstrual cycle. The presence of a gestagen component when taking oral contraceptives may result in both intensification and regression of the sign of androgenization. Thus, it is clear that the remaining generation of gestagens - gestodene, desogestrel, norgestimate - have a minimal androgenic effect. Therefore, low-dose OCs, which counteract gestagens, are more likely to stagnate in case of weak manifestations of androgenization. The most effective is OK for GA of ovarian gait. The mechanism of its action is suppression of ovulation, galvanization of the secretion of gonadotropins and endogenous ovarian hormones, androgen secretion. So, during the period of continuous therapy with OK, the ovaries can change over time due to the suppression of the production of gonadotropins, they should not be used for a period of time with hypothalamic and supra-narcotic forms of GA.

Prosti (“pure”) antiandrogens. Before “pure” antiandrogens are drugs, the main mechanism of which lies in the reduced utilization of androgens in the periphery and, to a lesser extent, their synthesis. They are divided into half-steroid and non-steroidal approaches. Recently, information has emerged about the use of finasteride, which is an antagonist of 5-β-reductase, which does not replace RA and does not influence the power of steroid hormones, and does not affect the gonadotropic function of the pituitary gland and does not reduce gonadotropins. It is mainly used for the treatment of prostatic hyperplasia; however, information has recently emerged about the success of stasis in women during the treatment of diseases accompanied by hirsutism and alopecia. It is shown that in 3 months. to take finasteride at a dose of 5 mg per dose. By avoiding a significant decrease in the level of T and DHT in the blood, the severity of hirsutism changes.

Other drugs in this group include flutamide, which has become increasingly popular among women since the 90s. The mechanism of action of this non-steroidal antiandrogen is explained by its effect on RA in target organs. The average therapeutic dose is 500 mg/dose; At higher doses, flutamide can be toxic to the liver. After 3-6 m. As a rule, there is a significant change in hirsutism, but given the data about the replacement of androgens in the blood, a significant decrease in androgens in the blood is not observed. However, some respondents have information about flutamide at a dose of 375 mg per dose. It is possible to reduce the level of testosterone and DHT in the blood. Thus, pure antiandrogens can be used in the treatment of diseases that are accompanied by androgenization. However, there is still insufficient evidence of vicinity in women, especially with regard to side effects, such as toxic release on the liver, which does not allow them to be widely recommended for practical stagnation.

Antiandrogens - progestogens. Drugs of this group have all the necessary power of antiandrogens and are considered the most effective, safe and available in clinical practice. One of the most active representatives of this group is cyproterone and cyproterone acetate (CPA) - synthetic hydroxyprogesterone with antiandrogenic and antigonadotropic activity.

Cyproterone has less antiandrogenic activity, lower CPA, so the rest deserves greater respect and is difficult to use widely. The mechanism of action of CPA is explained by its ability to replace RA and therefore progestagen authorities suppress the production of gonadotropins. Thus, by suppressing ovulation, CPA reduces the synthesis of state hormones in the ovary. In addition, it promotes the release of endorphins, counteracting the negative effect of androgens on endorphins, which is positively associated with sexual function, pain reflexes, and the emotional state of patients. Also, CPA was found to be effective in early adulthood in girls. So, the dose is 50-75 mg per dose. due to the stabilization of growth and regression of the previously violated secondary article signs. Prescribe CPA 10-50 mg from the 5th to the 14th day of the cycle as monotherapy or in combination with estrogens.

The drug we are most familiar with in gynecological practice is Diane-35, a hormonal contraceptive that is used in mild stages of hirsutism. The skin tablet contains 35 mcg ethinylestradiol and 250 mg CPA. As a rule, when androgenization occurs or the effect is insufficient with Diane-35 monotherapy for 6-9 months. It is recommended to include additional CPA (Androcur-10, 50) in the therapy in phase I of the cycle, 1 or more tablets per 15-day regimen, from days 1 to 15 of the cycle. This combined therapy is effective and has a lasting effect. It is recommended to take Diani-35 for a period of 12 months to reduce the severity of symptoms of hirsutism; for acne and alopecia, the effect begins quickly - on average after 6 months. Diane-35 is especially effective for complex therapy of diseases that are accompanied by PCOS, as it promotes regulation of the cycle, reduction of chronic estrogenic stimulation, decreased LH levels, and a change in the sign of androgenization ii, an increase in PSSG, a reduction in DHEA-S, a change in ovarian size, which promotes the effect. ovulation during infertility. CPA satisfies the main goals of antiandrogen therapy and is generally well tolerated by patients and well-tolerated by clinicians.

Spironolactone (veroshpiron)- an aldosterone antagonist 15 years ago was identified as an antihormone with a sechoginic effect, after which its expression of antiandrogenic power was revealed. SL in large doses suppresses the production of androgens in the ovary, although it does not interfere with the central mechanism of action, the dominant CPA. It appears that spironolactone interferes with the transition of testosterone to DHT. The best results are obtained with treated acne and seborrhea. Yogo is prescribed at 150-200 mg per dose. a course of 20-30 days for DSPPZ, and in this syndrome secondary aldosteronism is detected. Spironolactone is another drug of choice after CPA for symptoms of androgenization and may be recommended if a woman has contraindications or tolerance to CPA. To get the effect of your trace, freeze it as little as possible. The prescribed dose is 100 mg per dose. spironolactone reverses hirsutism and does not always reduce the level of androgens in the blood.

Before treatment with antiandrogens, it is necessary to establish the control of hyperandrogenism, turning off swelling, vomiting, and carefully follow etiopathogenetic therapy. Please also note contraindications for use and possible adverse reactions. Once the therapeutic effect has been achieved, completely reduce the dose and continue treatment with the stimulating regimen.

Upfront information to patients plays a great role. It should be noted that treatment may be necessary, which will not always allow the desired effect to be achieved, and after continued therapy, some signs of virilization may recur.

(Literature)

(1) Boroyan R. G. Clinical pharmacology for obstetricians-gynecologists. - M.: MIA, 1999. - 224 p.

(3) Mayorov M.V. Polycystic ovary syndrome: a current look // Provizor. - 2002. - No. 16. - P. 39-41.

(4) Gynecological disorders, prov. from English / For ed. K. J. Powerstein. - M., 1985. - 592 p.

(5) Pishchulin A. A., Karpova F. F. Ovarial hyperandrogenism and metabolic syndrome. - M.: Endocrinological Science Center of the Russian Academy of Medical Sciences. - 15 p.

(6) Podilsky V.V. Correction of hyperandrogenism in women with polycystic ovarian syndrome // Women’s reproductive health. - 2002. - No. 3. - P. 7-9.

(7) Reznikov A. R., Varga S. V. Antiandrogens. - M., 1988.

(8) Starkova N. T. Clinical endocrinology. Care for doctors. - 1991. - 399 p.

The latest list of literature is on the website

When dealing with antiandrogenic drugs for women, many people are prescribed food, which infusion of stench is put on the body and in which episodes are attributed. To understand this nutrition, it is necessary to consider the principle of the influx of androgens into the body of representatives of human and female articles.

Androgens are human steroid hormones that determine the functioning of human organs and the appearance of characteristic external signs in humans. The stench of the great mass is vibrating from the nasal plants and the bark of the overlying weeds. These representatives of strong status have a low timbre in their voices, an out-of-tune meat system, a beard and a vusa.

The group of androgens includes the following human hormones:

androstenediol;
androsterone;
androstenedione;
testosterone;
dihydrotestosterone.

All androgens are present in the blood of people. As the investigators established, many of them are produced by ovaries and supernal glands in the bodies of females. Here the stench is responsible for the regulation of the menstrual cycle and the growth of hair in intimate places.

In addition, we were able to demonstrate that several groups of steroid hormones take an active part in formed bone tissue, stimulate the production of other hormonal substances and lipids, and regulate the functions of sweat and sebaceous glands .

In some episodes, there is a surge in the production of androgens and their quantity increases rapidly. This is the so-called masculinization, in which a woman develops characteristic human signs: hair grows on the chin and above the upper lip, hair begins to appear on the back, buttocks and abdomen. The functions of sebaceous tissues suffer, which manifests itself as problems with the skin (seborrhea, acne, etc. are to blame).

As the rhubarb of androgens flows into the work of internal organs, pathologies of the ovaries, thyroid gland and suprathyroid gland develop. Often the result of hormonal imbalance is disruption of the menstrual cycle, sudden abortions and infertility.

To determine the level, it is recommended to perform tests instead of testosterone. In some cases, a different diagnosis is necessary, which makes it possible to turn off new creation in the supraneural organs and ovaries. The results are monitored as a medicinal drug using antiandrogens.

Characteristics of antiandrogens

Regardless of the reasons for the increase in the level of human hormone in the blood of a woman of good health, medications of the antiandrogen group are used to regulate the hormonal balance. Smells not only reduce the production of androgens, but also cause them to flow into the internal organs.

With the infusion of drugs, hormonal substances disintegrate in storage and are eliminated from the body in a natural way. Over the years, the symptoms of masculinization disappear, physical functions are normalized, and the woman develops characteristic external signs.

Current antiandrogens are divided into 2 types. If stored in a chemical warehouse, stench may be:

Steroid;
non-steroidal.

Oblivion is influenced by the interaction of human hormones with the receptors of the ovaries, measles of the epithelium and other organs. In addition, steroid drugs reduce the production of androgens, affecting the pituitary gland, which is the main “core” center of the process.

Antiandrogenic drugs are also used in the treatment of infertility, uterine fibroids and endometriosis.

Types of drug release forms

Nowadays, the pharmaceutical industry produces medications of the antiandrogen group in the form of tablets, capsules, dragees, aerosols, sprays, and formulations for injectable and subcutaneous administration.

Steroid products are produced on the basis of synthetic progestins: cyproterone acetate (CPA), chlormadinone acetate, spironolactone and dienogest. The greatest activity is shown by drugs that contain biologically active CPA.

These are the medicinal uses, such as:

Androcur is available in tablet form and in different sizes. Indicated for (body hair and skin) in women, androgenetic alopecia (alopecia), seborrhea, moderate and severe stages of acne, severe inflammation, scars and knots. Contraindications for people who suffer from liver disease, anemia, meningiomas, severe depression and fibrotic diabetes with angiopathy, with thrombosis and thrombophlebitis, during pregnancy and breastfeeding.
Klimen is an anti-menopausal drug that is produced in the form of a pellet. It has a clear antigonadotropic, antiandrogenic and gestagenic effect. Indicated for women of the reproductive age to regulate menstruation and reduce irregular bleeding from the uterus. The drug relieves the symptoms of menopause (hot flashes, sleep disturbance, sweating, nervous restlessness, heart palpitations, confusion, etc.), relieves dryness of the mucous membranes of the body’s organs. Endometrial cancer and hyperplasia are the most common culprits. Cosmetology enhances old skin, thus naturally vibrating collagen. Contraindications include thrombosis and thromboembolism, breast cancer, bleeding of unknown etiology, liver pathology, vaginosis and breastfeeding.
Diane-35 is an antiandrogenic drug in the form of pills. Indications before use for reducing vagusity in women with symptoms of androgenization (alopecia, acne, hair growths of the human type). It is not recommended to use vicoritis in case of dermatoses, liver disease, vaginosis, endometrial or breast cancer, or impaired fat metabolism.
Chloe is a combination contraceptive that has a gestagenic and antiandrogenic effect. It is recommended for clinical therapy for women with alopecia, acne, mild forms of hirsutism. It is prescribed as a contraceptive drug during androgenization. It is recommended to treat thrombosis and thromboembolism, hormone-dependent swelling, uterine bleeding, neurological migraines, angina pectoris and other cardiovascular diseases. The drug is not prescribed for vaginosis, pediatrics and women over 40 years of age.

Non-steroidal faces

Non-steroidal drugs of the antiandrogen group can be produced in the form of tablets or ointments.

These drugs include:

Flutamide is used externally for the treatment of hirsutism. Not recommended for people who suffer from illness or pregnancy. Use caution in cases of cardiac and vascular pathologies and predisposition to thrombosis.
Finasteride is not used in the treatment of female pathologies, but there is a clear expression of teratogenic power, which threatens to penetrate into the homeland. Women of reproductive age and age need to avoid contact with sexual partners in order to avoid this medicinal benefit in therapy.
Flutapharm can be used to treat hirsutism and menstrual cycle disorders in women. Not recommended for liver or thyroid pathologies. Zastosuvannya is surrounded by times of heart-judgment illness.

Currently, research is being carried out directly on the development of antiandrogenic drugs, which will directly influence the improvement and enhancement of reproductive function in both women and men, including in cases of congestion. new therapy for infertility.

Hyperadrogenism is a condition of the body that has too much androgens, as well as the consequences of their influx into the human body. As a rule, in women there is virilization (displaying human-like features), in men there is an increase in the size of the mammary ducts (gynecomastia), as well as impotence. Androgens are steroid hormones, their vibration is produced in the ovaries and testicles, in women and men. The supernal organs also vibrate this group of hormones.

Symptoms of hyperandrogenism

There may be many symptoms of hyperandrogenism, but the main ones can be seen:

Hirsutism. Abnormal hair growth on the surrounding parts of the woman's body, similar to the human type. Denmark has almost always suffered from the widest prevalence of hyperandrogenism. Hair can appear everywhere, such areas as the face, life, and also the breasts are covered with scalp. Wartly note the fact that due to the symptoms of abnormal hair growth, hair loss on the scalp can be avoided.

Ale hirsutism cannot be confused with hypertrichosis. Hypertrichosis is simply abnormal hair growth, but is usually not associated with hormonal imbalance. Also to blame is the racial identity of the woman. For example, women from Central Asia may experience more symptoms of hair loss than Europeans and Americans.

Acne. Peeling skin and acne also accompany hyperandrogenism.
Abnormal interruptions in the menstrual cycle. Rehabilitation can be from the monthly intervals to the third intervals in between.
It's funny and obese. Most often, the problem arises from the improper functioning of the overhangs.
Insignificant muscle atrophy, atrophy.
Decreased immunity and, as a consequence, more frequent infections.
Anomalies of external organs.
Damage to the nervous system, nerve disorders, depression, sleep disturbance.

Causes of androgenia guilt

Androgens are a group of hormones that produce more of them in women before the age of hair growth. However, there are reasons why this camp remains unchanged.

Multiple brushes of ovaries. The condition is more often accompanied by disturbances in the menstrual cycle, and anemorrhea (absence of menstruation) may occur. The inheritance of polycystic ovary syndrome is hirsutism, problems with pregnancy, and infertility.
Disruption of the endocrine system, cellular diabetes along with obesity become precursors to hirsutism, more than 20% of cases.

Today, nutrition is very urgent in order to reduce the manifestation of such an unacceptable manifestation as hirsutism. With the appearance of an unacceptable symptom, the bitterness of life is absorbed; a woman, who is motivated by the flow of androgens, faces a number of problems, even to the point of degeneration of physical organs.

Specifics and methods for treatment of androgenia

In women who treat hyperandrogenism, take additional drugs that suppress illness, which are called antiandrogens. Antiandrogenic drugs for women – these are oral contraceptives or antihypertensive agents in tablet form. These drugs are made up of two components:

Histogenic component. Typically, it includes testosterone, progesterone or spirolactone.
Ethinylestradiol. You can use oral contraceptives in both high doses and microdoses.

The main power of the components of the histogenic type is their structure.

However, it is important to note that the use of oral contraceptives can prevent unwanted side effects in women:

stimulation of androgen receptors;
Increasing the level of free testosterone in the blood, which results from the increase in testosterone levels due to interaction with the DES;
Decreased CVD levels in the liver, which increases the level of free testosterone in the blood of women.

These undesirable negative effects can be seen in cases of severe acne, acne, high cholesterol, atherosclerosis, a possible risk of diabetes, obesity, and also due to increased growth of meat mass.

In order to effectively treat hyperandrogenism and acne, it is possible to recommend before use such drugs as those included in the group of oral contraceptives. These drugs have a strong antiandrogenic effect, have a gentle effect on the female body as a whole, regulate the menstrual cycle, and also provide unparalleled protection in the face of unwanted vaginosis.

The German pharmaceutical company "Schering" allows you to select the necessary stock of oral contraceptives and offers a wide selection.

Diane-35 (0.035 mg ethinylestradiol and 2 mg cyproterone acetate),
Janine (0.03 mg ethinylestradiol and 2 mg dienogest),
Yarina (0.03 mg ethinylestradiol and 3 mg drospirenone).

All presented drugs are subject to registration in the Russian Federation. In order for mothers to have a clearer understanding of oral contraceptives, it is important to look at the skin of them.

Diani-35

The action of the drug is based on the following principles:

Vikid pituitary luteinizing hormone;
Eventually, androgens begin to look like ovaries and epithelial cells;
Cyproterone acetate (vitamin), has the power to suppress androgen hormones. However, it is important to note that the component can be suppressed not only by hormones that are produced in the ovaries and glands, but also by hormones that are produced in the skin and adipose tissue.

The drug must be taken from the first day of the menstrual cycle and continued for 21 days, without missing or painful breaks. Then there is a seven-day break, during which menstruation begins, and on the eighth day the onset course of taking the drug Diane-35 is started again.

Janine

Dienogest is the basis of such an oral contraceptive as Janine. This resin is a histogenic component. The action of deinogest is similar to that of natural progesterone.

Looking at the oral contraceptive Janine, it is necessary to take into account its antiandrogenic effects:

Suppression of androgen production by the ovaries;
Includes an increase in testosterone due to interaction with SSD;
Delapet can produce DES in the liver, and it can also change the amount of testosterone in the bloodstream.
The drug does not affect the synthesis of FSH and LH (gonadotropic hormones).

Yarina

Veroshpiron or spironolactone is the essence of such an oral contraceptive as Yarina. Treatment with the drug causes blocking of skin receptors to androgen hormones. Androgens are blocked and are the main metaactive component. However, it is important to note that Yarina does not have such a strong blocking effect as, for example, the oral contraceptive Diane-35. This drug is recommended for regulating the menstrual cycle and is indicated for women over thirty years of age. The additional dose of rechovini is 200 mg.

The action of this drug is offensive:

Blocking of skin receptors to androgen hormones;
Suppressed synthesis of hormones LH and FSH;
Does not reduce testosterone levels from the lancet to the DES;
It helps synthesize dry hormones in the liver, and also reduces testosterone in the blood.

Yarina's hormonal contraceptive is recommended for use in women for the treatment of acne in another part of the menstrual cycle. It also has a significant therapeutic effect in the fight against obesity. When using such antiandrogenic drugs as Yarina, Zhanin and Diani-35, it is important to note that increased symptoms can begin to be avoided no earlier than the third month of the feast.

Under the influence of the drugs, the skin color improves, the menstrual cycle becomes regular, and body weight does not increase. It is necessary to note that a drug such as Yarina, in conjunction with the treatment of hyperandrogenism, alleviates a decrease in a woman’s vaginal indicators. However, the preparation must be used at least as quickly as possible to achieve a visible effect.

Only highly qualified doctors are to blame for the signs of oral contraceptives becoming stale. Before choosing one of the drugs, as well as determining the tactics for treating such a syndrome as hyperandrogenism, it is necessary to carry out all the tests on the body, as well as perform a thorough blood test and a blood test for a large number of hormones.

Alternative methods of reducing androgens

It should be noted that in our time, in addition to hormonal oral contraceptives, there are also alternative ways to reduce androgens in a woman’s body. Excessive hair loss, human hair type, as well as acne and the normal amount of fat visible in the skin are problems associated with the development of increased testosterone and decreased estrogen.

Therefore, hormonal drugs are used to alleviate problems. It should be noted that in order to treat such inadequacies, antiandrogenic approaches are often used, which have also proven to be beneficial. The use of drugs has been proven both by science and by the special knowledge of women who suffer from illness.

However, it is important to note that uncontrolled use and treatment of preparations and infusions with antiandrogenic activity can lead to negative effects, so their use is not under the supervision of a physician.

In case of reduced estrogen level, the following warehouses can help:

Hog queen. It has definitely recommended itself for such problems as a decrease in the level of estrogen. If it is determined that testosterone is superior to estrogens, then the herb in infusions will help raise the level of estrogens, which will reduce the level of testosterone.
Fennel and geranium. And the very essential oils of these plants that are used for aromatherapy, internal and external stagnation, if the stagnation of the oils is uncontrolled, such dangerous consequences as uterine bleeding can develop.

However, with this method of combating hyperandrogenism by increasing the level of estrogen, be careful, since an uncontrollably high level of estrogen can cause swelling.

Warehouses of decreased androgen levels

Mint. Mint is good for reducing testosterone levels. By drinking rose tea two times a day, you will effectively reduce the level of testosterone in your body;
Stevia. This herb is considered a natural substitute for vegetable oil. There's a sweet taste there. By drinking this herbal tea, you can effectively reduce the level of androgens in a woman’s body;
Watermelon extract, watermelon oil or pharmaceutical zinc are useful for lowering testosterone levels;
Science knows another way to eliminate androgens in the female body - by taking medications for men that are effective against prostate adenomas. Such drugs should only be taken after consultation with a doctor, and can be supplemented at the pharmacy.

It is important to note that medicinal properties have a significant effect when combined with such components as a vitamin complex, including vitamin B6 and zinc.

It is necessary to pay attention to the fact that all alternative methods of treating hyperandrogenism may have a cumulative effect and they can be noticed not sooner than after a short period of stagnation. And also phytowarehouses have an important function, since the problem is purely cosmetic, and if skin irritation is partly a complex disease, then the cause must be looked for in the body and take more complex therapy.

Finally, it is important to note that hyperandrogenism is a condition that requires careful treatment and care. It is impossible to solve the problem on your own. After carrying out the necessary closure, the doctor will provide adequate care in order to resolve the problem as soon as possible. This is due to the fact that only adequate love can give a positive result. And self-indulgence can have a detrimental effect on the quality of life.

Androgens are special hormones that are responsible for the functioning of organs in the human body. These speeches themselves indicate the timbre of the voice and the appearance of a representative of a strong position. However, due to low levels of function, androgens can accumulate in the female body. In this case, the effect they have on girls and women may be completely insignificant. If the blood level goes off scale, you have to take special antiandrogenic drugs and medications.

What is the function of androgen?

Androgens are responsible for the normal functioning of human organs. In addition, these words indicate the importance of bone tissue, and are also responsible for the vibration of other hormones. Androgens themselves control the normal functioning of sebaceous glands. Hormones and antiandrogen drugs and severe acne are not commonly used. Since the quantity of state hormones in the female body is high, the menstrual cycle is not disrupted. If there are any problems with the sechostatal system in a weak woman, the gynecologist will conduct tests to determine the presence of hormonal imbalances.

If the quantity exceeds the norm, human characteristics may be lost. This increases the amount of hair on the face, giving a higher view of the skin secretion. There can also be disastrous consequences that lead to infertility or the inability to bear a healthy baby. In this age group, women simply need antiandrogenic drugs. A better treatment can be considered as a medicine.

Reasons for and inheritance of increased levels of androgens in women

Most of the products in cosmetology salons are for women with hyperthyroidism instead of human thyroid hormone. We are about to lose the functions of the sebaceous glands. Girls are already beginning to suffer from a serious form of acne. After 30 years of age, women begin to experience significant growth of facial hair. Most of the time, who are allowed to clean up, the apparently unfavorable people are hairy with a mechanical path. It is necessary for women to take antiandrogen drugs. In most cases, hair appears above the upper lip. They can first be observed on the chin, thighs, back and abdomen.

Antiandrogens may be indicated in cases of disruption of the normal functioning of the epithelial glands. In addition, patients may have enlarged thyroid glands and ovaries. Treatment may be complex and may only take place under the supervision of a doctor.

The development of human signs may be caused by changes in testosterone in the woman’s blood. Often such a stoma is cut in case of serious pathologies of internal organs. Problems occur if antiandrogen drugs for women do not produce the desired results. The treat will require prompt delivery.

How do Russian antiandrogens work?

Regardless of the increased amount of androgens in a woman’s body, most women with seizures require special depressants. Medicines can be taken on their own or included in complex therapy. Medicines control the fluctuation of human hormones, and also prevent them from leaking into internal organs.

All synthetic or natural antiandrogens are divided into steroids and non-steroids. The rest respond to changes in human hormones, flowing into the pituitary gland of the brain. Therefore, the use of such drugs should only be carried out under the supervision of a doctor. It is not recommended to treat therapy abruptly. The dosage of antiandrogenic drugs gradually changes as long as the doctor maintains positive dynamics. Below we will present the most popular current drugs with an antiandrogenic effect.

"Androcur"

A popular antiandrogenic drug that is available in the form of tablets and powder for injection. In addition, the medicinal stock includes corn starch, silicon dioxide, lactose monohydrate, and also the most commonly prescribed medication in the form of tablets. The drug is suitable for these types of episodes, if the increase in human hormone leads to such effects as an important form of acne or seborrhea, hair loss in women. Treatment (antiandrogens) in such cases should be selected carefully. Adje ci drugs may be contraindicated.

It’s not the fault of Androcur. The drug can be prescribed to people when a new growth appears in the anterior ovary, as well as pathological symptoms associated with static behavior. With additional injections or Androcur tablets, you can significantly reduce sexual desire. It is not recommended to take the drug on your own.

When choosing antiandrogenic properties and drugs, descriptions and instructions must be read to us in advance. With particular respect, please note the following contraindications. The drug "Androkur" is contraindicated for liver disease. If this area has previously been swollen or has been removed, the medication should be taken carefully. Androkur tablets are not prescribed to patients with pancreatitis, Rotor syndrome, diabetes or chronic alcoholism. Vikoryism to women who are pregnant and fertile is strictly forbidden.

In the hour of medicinal care, one is oftenware of side effects that may turn out to be negotiable. There are signs of sudden changes in mood, depression, tearfulness, fatigue and apathy. If such symptoms appear, continue taking the drug. And if sensitivity is increased to the point of speech, the drug “Androcur” should be taken away.

"Visanne"

The medicinal effect is related to the group of non-steroids and has anti-tumor activity. The drug is produced in the form of pellets. The main component of this drug is bicalutamide. In addition, the medicine contains lactose, silicon dioxide, and magnesium stearate. Medicines are used most often for the treatment of endometriosis, as well as damage to the female sechostatic system. The drug is strictly contraindicated. Therefore, take this trace quickly under the watchful eye of the fakhivtsa.

Visanna tablets should not be prescribed for bleeding, severe liver disease, or malignant swellings that may be of a hormonal nature. Contraindications include lactose deficiency, diabetes and chronic alcoholism. Androgens and antiandrogens should not be taken during pregnancy. Do not prescribe drugs from this group to patients of minor age.

In order for the treatment to give good results, it is important to carefully follow the correct dosage. Take the tablets once a day. It is important that the appointment takes place at the same hour every day. The treatment course cannot be interrupted every time. Most often, Visanna tablets are prescribed for a minimum of 6 months. Decisions about continuing therapy can only be praised by the doctor.

"Marvelon"

Which is related to the group of antiandrogenic drugs. The main component of this drug is desogestrel. In addition, the pharmaceutical stock includes lactose monohydrate, potato starch, silica oxide, and stearic acid. In most cases, Marvelon tablets are used as a means of protection due to unnecessary discomfort. Often, anti-androgenic anti-inflammatory contraceptives may also be used to address cosmetic problems, such as increased hair density and important forms of acne. In this case, Marvelon tablets are only included in complex therapy.

The drug is strictly contraindicated. There is no way to take it without the permission of the doctor. Medical treatment is not suitable for girls and women with diabetes, pancreatitis, severe liver disease, partial migraines, thrombophlebitis, lactose deficiency. The drug is anti-inflammatory. Therefore, it is ineffective for vagrant women to accept him. Women over 35 years of age, as well as Kurdish men, should take Marvelon tablets with caution. Girls with severe and moderate forms of obesity can only take the medication under the supervision of a doctor.

Taking tablets covers a 28-day menstrual cycle. Starting from the 7th day, girls must take one tablet every day for three days. Then take a break for 7 days. During this period, menstrual bleeding may occur.

"Janine"

Another popular contraceptive with an antiandrogenic effect. Like many other natural antiandrogens, “Janine” is available in the form of a pill. The products are created on the basis of dienogest. Lactose monohydrate, gelatin, magnesium stearate, and potato starch are also commonly used. Dragee “Janine” is immediately victorious for us as a defense against unnecessary vagusness. In addition, it helps to solve skin problems caused by changes in human state hormones in the blood. To blame for the disruption of the menstrual cycle, the medication may have other uses.

Take antiandrogenic drugs with caution. Daily acne therapy for women is carried out only under the supervision of a doctor. This means that contraceptives with an antiandrogenic effect may be contraindicated. We are immediately aware of the presence of thrombosis, cervical diabetes, serious illness of the liver, vaginal bleeding and unconscious gait. Do not use “Janine” tablets during pregnancy and lactation. Warehouses can cause serious damage to the development of the fetus. The first gynecologist will prescribe the drug to the woman and ask her to take a vaginal test.

The regimen for taking the drug is the same as for the Marvelon brand. If the method is used as contraception, the tablets should be taken without overfilling. Just forget about the medication for a day, and the desired effect will not be a problem.

"Logest"

A good oral contraceptive that successfully relieves androgen-dependent skin syndromes in women. The main active word is gestodene. The drug is produced in the form of dragees and tablets. You can only use contraceptive methods. It successfully alleviates the symptoms of a hormone deficiency in the female body. Logest tablets are prescribed for the treatment of acne and disruption of the menstrual cycle.

Contraindications prior to administration of the drug include thrombophlebitis, blood diabetes, sudden bleeding from the urinary tract, migraines of a neurological nature, liver failure. The drug “Logest” is not prescribed to girls under 15 years of age, as well as to women during pregnancy and lactation. In some cases, it may also be prescribed to patients who have entered menopause.

Tablets or dragees are taken during the menstrual cycle. I’ll stop bleeding until menstrual bleeding starts. Alternative contraceptives are antiandrogen drugs for women. The evidence shows that products with a similar effect significantly protect against unnecessary vomiting and avoid a lot of cosmetic problems.

"Spironolactone"

This antiandrogenic drug is most often used for the treatment of important forms of acne. Another substance is a magnesium-sparing diuretic, which controls the activity of sebaceous plaques. The medication is released in the form of pills. It can also become stagnant in the other half of the tension, if strong strains of the ends occur. Indications for the drug “Spinorolactone” are for women with irregular menstrual cycles, as well as polycystic ovarian disease.

Spinoronolactone tablets should not be prescribed to women with diabetes, nicotine or liver deficiency. In the first trimester of pregnancy, the medication is also contraindicated. Patients with thrombophlebitis and chronic alcoholism should take the drug with caution. In case of any emergency, a bath may be performed under the supervision of a doctor. It is very important to finish taking your dose. Likuvannya can last for 2-3 years. Next, take one tablet three times a day. You can adjust the dosage and severity of the course of treatment without taking the medicine.

Antiandrogen drugs for women. Products and prices

Regardless of the fact that medicinal properties with an antiandrogenic effect may command a high price, comments about them can be almost less positive. Especially a lot of good words can be found in girls with severe acne. In just a few courses, you can reduce the ignition process and normalize the work of sebaceous deposits. Most often, anti-androgenic drugs for women are used for these purposes. Prices for them range from 700 to 2000 rubles. The truth is not so small anymore. Let the positive words speak for themselves.

Choose an antiandrogenic option, relying only on the positive evidence of friends and relatives, in no way. Any medicine may be considered more than a doctor.

Anti-crash walks are the benefits of emergency medicine. The stench helps rich women to prevent unwanted vaginalness, and, as a result, to hide congestion. Before such COCs (combined oral contraceptives) there are tablets with an androgenic effect. They are used to regulate the level of state hormones that lie before humans – androgens. Sometimes, due to hormonal imbalance, the patient develops illnesses, inability to conceive, child guilt, and skin pathologies. Before the complex therapy, gynecologists also include anti-inflammatory tablets with an androgenic effect.

Who should choose hormonal contraceptives with an antiandrogenic effect?

Antiandrogenic is a form of the word “androgen”, which means human hormone. Vіn stands for showing external and internal signs of strong status. In women, androgens can outweigh estrogens, which affects life expectancy. In such a situation, doctors may prescribe anti-inflammatory tablets with an antiandrogenic effect. This helps to regulate the imbalance and eliminate the main manifestations of ailments.

Women can take COCs (combined oral contraceptives) with an antiandrogenic effect after consulting an endocrinologist or gynecologist. It is necessary to check the level of hormones in order to initiate therapy with pills or use them with contraception. A specialist can select the appropriate type of COC.

If the patient’s test results show a rise in the level of androgens, we can talk about the diagnosis of “hyperandrogenism”. It is important to notice the following symptoms. Their manifestation is seen as an indication before the use of antihypertensive pills with an antiandrogenic effect:

disruption of the menstrual cycle;
supramiral sebaceous activity on the surface of the dermis;
there is darkness in the area;
accelerated growth in girls;
collection of meat mass;
hair appears above the surface on the face, belly, and inner part of the belly;
innocence of pregnancy, infertility.

As a rule, women who were first exposed to the use of COCs do not know that the stench emanates from a wide range of drugs. Anti-hypertensive pills may be used not only as a method of eliminating unnecessary vagusity. The drugs successfully treat infertility, hormonal imbalance, and skin pathologies.

In vodkas one can often sense buried vodka about the influx of anti-inflammatory effects on people. There it becomes clean, the visipanya goes self-tightening. It is true that gynecologists and endocrinologists are pleased to respect the given criteria for implantation of KZK.

As during therapy or contraception with pills with an antiandrogenic effect, the woman’s skin sagging increased and acne began to develop more often, taking this type of medication is recommended. Let's talk about nonsense. However, if the skin becomes red after taking COCs, we can talk about the correct choice of tablets.

Contraindications for the use of combined oral contraceptives

Hormonal anti-inflammatory pills, regardless of their effectiveness and versatility, may have a number of side effects and serious health problems if used incorrectly. Before you start taking medications, be sure to become familiar with the contraindications.

If a woman may be confused about one of the following points, it is not recommended to use COCs:

Restore your respect - eating chicken and taking anti-crack pills is not crazy!

This poses a greater risk of developing adverse reactions. It has been proven that almost 60% of patients who took COCs and injected nicotine will develop cardiovascular problems: thrombosis, varicose veins, arrhythmia.

List of short-term anti-inflammatory tablets with antiandrogenic action, pros and cons, price

Today's pharmacological market is clear with the choice of anti-inflammatory tablets with an antiandrogenic effect. It is important for women to make a choice. Most people don’t know what to look for, what are the pros and cons for each person. The table below will help you look at the most popular and most effective antiandrogen pills and make the right choice.

Name	Pros	Minuses	Average varity
Diani – 35	Regulation of hormonal levels and the menstrual cycle. Helps with complex treatment of gynecological problems.	A great variety of side effects. After treatment, not all women with hyperandrogenism are suitable. High varity.	850 rub.
Logest	The strength of the formulation is suitable for most women, there is a small list of contraindications and side effects.	Increased vagina, decreased sexual activity, libido.	720 rub.
Yarina	Normalize the menstrual cycle, it will go smoothly, sagging on the skin, and ease of stiffness will occur. Involvement in the treatment of polycystic ovarian disease, dysmenorrhea, endometriosis.	High levels of anxiety, frequent side effects such as headaches and mood swings.	800 rub.
Janine	Suffer from complex treatment of polycystic ovarian disease, dysmenorrhea, endometriosis, infertility. Helps regulate and renew the menstrual cycle.	Often there are side effects such as a set of symptoms, depression. High varity.	800 rub.
Jess	Hand-packed for easier handling, instructions before drying. Renew the menstrual cycle, eliminate inflammation processes with complex therapy.	High varity. List of contraindications.	900 rub.
Marvelon	It is considered as a complex therapy for inflammatory processes in the ovaries and mother. Helps renew the menstrual cycle.	There is a long list of side reactions that often manifest themselves as headaches, weakness and pain in the chest.	640 rub.
Tri-Mercy	Renewal of the menstrual cycle, sagging on the skin. Average varity.	Adverse reactions often occur. Many women indicate an increase in milk production, vaginal gain, and decreased libido.	650 rub.

How to take oral contraceptives correctly? The table shows anti-hyperandrogenic tablets, which in the last 5 years have shown high effectiveness in treating hyperandrogenism. This is the name of a COC with an antiandrogenic effect, remember that a woman has signs of hormonal imbalance. In consultation with a gynecologist, you can select the appropriate medication after the tests are completed and the procedure is completed.

If a woman first begins to take pills on her own, she is faced with a lack of nutrition until the shortest hour of getting ready for stagnation, so that she can work every time she skips it. The information on this food may contain instructions from drying. If for some reason it is not available, you can rely on standard recommendations for taking COCs. Stinks lie at the foot:

it is necessary to choose the same hour to take contraceptives;
Start taking pills on the first day of the menstrual cycle;
the course of therapy must be continued until all the tablets in 1 blister are finished;
Then it is recommended to take a break of 7 days for the onset of the menstrual cycle;
regardless of the completion and appearance of menstruation, printing after the end of the current term by taking a new blister;
If a contraceptive dose was missed, it is recommended that you renew it earlier, within 12 years;
If you start vomiting after taking the tablets, then take the medication again;
If vomiting is repeated throughout the day, doctors recommend taking medication at any time and quickly using other methods of escape;
If you do not take the therapy, bloody vision will appear until the blister runs out (to talk about the hormonal imbalance).

If you follow all the recommendations of the doctors, anti-inflammatory tablets with a cosmetic effect will become a useful aid. Consultation with a physician will help reduce the risk of adverse reactions and complications. Gynecologists and endocrinologists have great evidence that they prescribe tablets based on the patient’s body weight, individual characteristics, concomitant pathologies, and eyelids.